KalVista Pharmaceuticals, Inc. KALV faced a major setback when it decided to terminate the phase II KOMPLETE study evaluating its investigational oral plasma kallikrein inhibitor, KVD824, for the prophylactic treatment of hereditary angioedema (HAE) earlier this week.The KOMPLETE study was evaluating KVD824 for the prevention of attacks in adults with HAE.The company decided to terminate the study based on the observation of liver enzyme (ALT/AST) elevations in several patients across all treatment groups. None of the patients in the study had a concomitant elevation of bilirubin levels and all were asymptomatic.Shares of KALV crashed on the abovementioned news. The stock has declined 61.1% so far this year compared with the industry’s decrease of 26.2%.Image Source: Zacks Investment ResearchThis apart, KalVista is also developing sebetralstat (formerly KVD900) for treating patients with acute HAE attacks.The company is currently enrolling patients in the phase III KONFIDENT study, which is investigating sebetralstat as an oral on-demand treatment for acute HAE attacks. Data from the same is expected in the second half of 2023.Per the company, sebetralstat is a compound from KVD824 and no treatment-related liver enzyme elevations have been observed in any of the clinical studies on sebetralstat.KalVista has also completed a phase II study on another candidate, KVD001, for the treatment of diabetic macular edema.We note that KalVista currently has no approved products in its portfolio. Hence, in the absence of a marketed drug, pipeline development remains in key focus for the company. However, similar pipeline setbacks could hurt the stock in the days ahead.Zacks Rank & Stocks to ConsiderKalVista currently carries a Zacks Rank #3 (Hold). Some better-ranked stocks in the same sector are Infinity Pharmaceuticals, Inc. INFI, Phio Pharmaceuticals Corp. PHIO and Calithera Biosciences, Inc. CALA, all carrying a Zacks Rank #2 (Buy) at present. You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.Estimates for Infinity Pharmaceuticals’ loss per share have narrowed 11.5% for 2022 and 13.3% for 2023 in the past 60 days.Earnings of Infinity Pharmaceuticals surpassed estimates in each of the trailing four quarters. INFI delivered an earnings surprise of 7.14%, on average.Estimates for Phio Pharmaceuticals’ earnings per share have increased 40.4% for 2022 and 13% for 2023 in the past 60 days.Earnings of Phio Pharmaceuticals surpassed estimates in three of the trailing four quarters and missed on the other occasion. PHIO delivered an earnings surprise of 21.32%, on average.Estimates for Calithera Biosciences’ loss per share have narrowed 37.3% for 2022 and 39.8% for 2023 in the past 60 days.Earnings of Calithera Biosciences surpassed estimates in three of the trailing four quarters and missed on the other occasion. CALA delivered an earnings surprise of 21.08%, on average. Zacks Names "Single Best Pick to Double" From thousands of stocks, 5 Zacks experts each have chosen their favorite to skyrocket +100% or more in months to come. From those 5, Director of Research Sheraz Mian hand-picks one to have the most explosive upside of all. It’s a little-known chemical company that’s up 65% over last year, yet still dirt cheap. With unrelenting demand, soaring 2022 earnings estimates, and $1.5 billion for repurchasing shares, retail investors could jump in at any time. This company could rival or surpass other recent Zacks’ Stocks Set to Double like Boston Beer Company which shot up +143.0% in little more than 9 months and NVIDIA which boomed +175.9% in one year.Free: See Our Top Stock And 4 Runners UpWant the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Infinity Pharmaceuticals, Inc. (INFI): Free Stock Analysis Report Calithera Biosciences, Inc. (CALA): Free Stock Analysis Report KalVista Pharmaceuticals, Inc. (KALV): Free Stock Analysis Report Phio Pharmaceuticals Corp. (PHIO): Free Stock Analysis Report To read this article on Zacks.com click here. Zacks Investment Research