Denali Therapeutics’ DNLI shares rose 4.4% on Nov 5, after the company reported third-quarter results and positive pipeline updates.Denali incurred a loss of 69 cents per share for third-quarter 2021, wider than the Zacks Consensus Estimate of a loss of 51 cents and the year-ago loss of 54 cents, primarily due to higher expenses and lower revenues.Collaboration revenues came in at $5.3 million for the reported quarter, missing the Zacks Consensus Estimate of $25 million and declining from $9.4 million in the year-ago period. The year-over-year decline was primarily owing to a decrease in revenues from the company’s collaboration with Takeda TAK, driven by a decrease in costs incurred in the partnered programs.In the year so far, Denali’s shares have declined 34.3% compared with the industry’s 12.4% decline.Image Source: Zacks Investment ResearchQuarter in DetailResearch and development expenses were $71.6 million for the quarter under review compared with $53.7 million in the year-ago period, primarily driven by an increase in personnel-related costs.General and administrative expenses were $19.3 million, up from $15.8 million in the year-ago quarter due to an increase in personnel-related costs, including stock-based compensation, primarily due to higher headcount and additional equity award grants.Cash, cash equivalents and marketable securities were approximately $1.4 billion as of Sep 30, 2021.Recent UpdatesIn September, the company announced that it initiated dosing participants in a phase Ib study with DNL343, its brain-penetrant small molecule activator of EIF2B, in amyotrophic lateral sclerosis (ALS) patients. Denali initiated the study on the basis of positive data from preclinical and phase I studies, wherein DNL343 achieved safety and biomarker goals.Denali also announced additional positive interim data from a phase I/II study evaluating ETV:IDS (DNL310), an investigational brain-penetrant enzyme replacement therapy intended to treat both central nervous system and peripheral manifestations of Hunter syndrome in July 2021. Based on this data, the company will initiate a pivotal phase II/III study in first-half 2022 and is currently enrolling patients in Cohort C of the phase I/II study to further evaluate the clinical endpoints of the study in patients aged below four years in Hunter syndrome.Last month, Denali announced that partner Sanofi SNY plans to initiate a phase II HIMALAYA study in first-quarter 2022 to evaluate the efficacy and safety of RIPK1 inhibitor, DNL788, in adult patients having ALS.The company also plans to initiate late-stage clinical development of its LRRK2 inhibitor, DNL151, in Parkinson's disease. DNL151 is being developed in collaboration with Biogen BIIB.Denali Therapeutics Inc. Price Denali Therapeutics Inc. price | Denali Therapeutics Inc. QuoteZacks RankDenali currently has a Zacks Rank #5 (Strong Sell).You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here. Bitcoin, Like the Internet Itself, Could Change Everything Blockchain and cryptocurrency has sparked one of the most exciting discussion topics of a generation. Some call it the “Internet of Money” and predict it could change the way money works forever. If true, it could do to banks what Netflix did to Blockbuster and Amazon did to Sears. Experts agree we’re still in the early stages of this technology, and as it grows, it will create several investing opportunities. Zacks’ has just revealed 3 companies that can help investors capitalize on the explosive profit potential of Bitcoin and the other cryptocurrencies with significantly less volatility than buying them directly. See 3 crypto-related stocks now >>Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Sanofi (SNY): Free Stock Analysis Report Biogen Inc. (BIIB): Free Stock Analysis Report Denali Therapeutics Inc. (DNLI): Free Stock Analysis Report Takeda Pharmaceutical Co. (TAK): Free Stock Analysis Report To read this article on Zacks.com click here. Zacks Investment Research